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ea0037gp.29.01 | Endocrine tumours and neoplasia – Adrenal Tumour | ECE2015

Mitotane inhibits sterol-o-acyltransferase leading to lipid-mediated endoplasmic reticulum stress and apoptosis of adrenocortical carcinoma cells

Sbiera Silviu , Fassnacht Martin , Leich Ellen , Liebisch Gerhard , Schirbel Andreas , Wiemer Laura , Matysik Silke , Vanselow Jens T , Gardill Felix , Gehl Annemarie , Kendl Sabine , Beyer Melanie , Bala Margarita , Ronchi Cristina L , Deutschbein Timo , Schlosser Andreas , Schmitz Gerd , Rosenwald Andreas , Allolio Bruno , Kroiss Matthias

Context: Mitotane is the only drug approved for treatment of adrenocortical carcinoma (ACC) and in clinical use for more than 50 years. Mitotane counteracts both tumour growth and tumoral steroid hormone production but treatment is associated with severe side effects. The molecular mechanism of mitotane is still unknown, which hampers progress in treatment of ACC.Objective: To identify the mechanism of action and molecular target of mitotane.<p class...

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Endocrine Abstracts

Mitotane inhibits sterol-o-acyltransferase leading to lipid-mediated endoplasmic reticulum stress and apoptosis of adrenocortical carcinoma cells

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